Journal article
C. Park, Yi-fu Yang, Xuyu Zhou, K. Toyo-oka, Y. Yashiro‐Ohtani, W. Park, M. Tomura, X. Tai, T. Hamaoka, H. Fujiwara
2002
2002
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APA
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Park, C., Yang, Y.-fu, Zhou, X., Toyo-oka, K., Yashiro‐Ohtani, Y., Park, W., … Fujiwara, H. (2002). Reversible CD8 expression induced by common cytokine receptor γ chain-dependent cytokines in a cloned CD4+ Th1 cell line.
Chicago/Turabian
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Park, C., Yi-fu Yang, Xuyu Zhou, K. Toyo-oka, Y. Yashiro‐Ohtani, W. Park, M. Tomura, X. Tai, T. Hamaoka, and H. Fujiwara. “Reversible CD8 Expression Induced by Common Cytokine Receptor γ Chain-Dependent Cytokines in a Cloned CD4+ Th1 Cell Line” (2002).
MLA
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Park, C., et al. Reversible CD8 Expression Induced by Common Cytokine Receptor γ Chain-Dependent Cytokines in a Cloned CD4+ Th1 Cell Line. 2002.
BibTeX Click to copy
@article{c2002a,
title = {Reversible CD8 expression induced by common cytokine receptor γ chain-dependent cytokines in a cloned CD4+ Th1 cell line},
year = {2002},
author = {Park, C. and Yang, Yi-fu and Zhou, Xuyu and Toyo-oka, K. and Yashiro‐Ohtani, Y. and Park, W. and Tomura, M. and Tai, X. and Hamaoka, T. and Fujiwara, H.}
}
Abstract
T cells that are intrathymically lineage committed are believed to maintain their CD4 or CD8 co-receptor expression. Here, we investigated whether intrathymic lineage commitment involves irreversible genetic modification or whether co-receptor expression can be reprogrammed depending on external stimuli. The CD4(+) T(h)1 clone 2D6 established from splenic T cells as an IL-12-dependent line survived in culture with IL-2, IL-7 or IL-15 alone. Surprisingly, CD8 expression occurred in 2D6 cells upon replacement of IL-12 with any one of the three cytokines that stimulate the common cytokine receptor gamma chain, yielding CD4(+)CD8(+) 2D6 cells. CD8 expression declined when IL-2 was replaced with IL-12 and CD8 induction was inhibited when IL-12 was included in IL-2 or IL-7 culture. Our observations show that even a lineage-committed mature T cell can be reprogrammed for co-receptor expression in response to particular external stimuli.