Toyooka Lab

Translational Research for Autism & Parkinson's Disease

The cytoplasmic localization of ADNP through 14-3-3 promotes sex-dependent neuronal morphogenesis, cortical connectivity, and calcium signaling


Journal article


Sarah A. Bennison, Sara M. Blazejewski, Xiaonan Liu, Gal Hacohen-Kleiman, Shlomo Sragovich, Sofia Zoidou, Olga Touloumi, Nikolaos Grigoriadis, Illana Gozes, Kazuhito Toyo-oka
Molecular Psychiatry, vol. 28(5), 2023, pp. 1946-1959


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APA   Click to copy
Bennison, S. A., Blazejewski, S. M., Liu, X., Hacohen-Kleiman, G., Sragovich, S., Zoidou, S., … Toyo-oka, K. (2023). The cytoplasmic localization of ADNP through 14-3-3 promotes sex-dependent neuronal morphogenesis, cortical connectivity, and calcium signaling. Molecular Psychiatry, 28(5), 1946–1959. https://doi.org/10.1038/s41380-022-01939-3


Chicago/Turabian   Click to copy
Bennison, Sarah A., Sara M. Blazejewski, Xiaonan Liu, Gal Hacohen-Kleiman, Shlomo Sragovich, Sofia Zoidou, Olga Touloumi, Nikolaos Grigoriadis, Illana Gozes, and Kazuhito Toyo-oka. “The Cytoplasmic Localization of ADNP through 14-3-3 Promotes Sex-Dependent Neuronal Morphogenesis, Cortical Connectivity, and Calcium Signaling.” Molecular Psychiatry 28, no. 5 (2023): 1946–1959.


MLA   Click to copy
Bennison, Sarah A., et al. “The Cytoplasmic Localization of ADNP through 14-3-3 Promotes Sex-Dependent Neuronal Morphogenesis, Cortical Connectivity, and Calcium Signaling.” Molecular Psychiatry, vol. 28, no. 5, 2023, pp. 1946–59, doi:10.1038/s41380-022-01939-3.


BibTeX   Click to copy

@article{sarah2023a,
  title = {The cytoplasmic localization of ADNP through 14-3-3 promotes sex-dependent neuronal morphogenesis, cortical connectivity, and calcium signaling},
  year = {2023},
  issue = {5},
  journal = {Molecular Psychiatry},
  pages = {1946-1959},
  volume = {28},
  doi = {10.1038/s41380-022-01939-3},
  author = {Bennison, Sarah A. and Blazejewski, Sara M. and Liu, Xiaonan and Hacohen-Kleiman, Gal and Sragovich, Shlomo and Zoidou, Sofia and Touloumi, Olga and Grigoriadis, Nikolaos and Gozes, Illana and Toyo-oka, Kazuhito}
}

Why is it important?

We found that Adnp plays an important role in neuritogenesis, spinogenesis, neural connectivity and neural activity. Additionally, we were able to identify the mechanisms by which Adnp distribution in neurons changes from the nucleus to the cytoplasm during neuronal differentiation via Adnp phosphorylation and binding to 14-3-3.

Perspectives

"I hope these findings provide an opportunity to understand in vivo Adnp functions and the etiology of ADNP syndrome and ASD.”
 
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Kazuhito Toyooka